2383 Amiodarone-Induced Acute Liver Injury

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Amiodarone-Induced Liver Injury and Cirrhosis

We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.

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Predictors of intravenous amiodarone induced liver injury

Background Intravenous (IV) amiodarone may be associated with liver injury that may necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) and its severity may help careful patient monitoring or the choice of other measures alternative to amiodarone in high risk patients. Little is known regarding predictors of AILI. Objectives To address the predictors of ...

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Alcohol consumption is customary in most cultures and alcohol abuse is common worldwide. For example, more than 50% of Americans consume alcohol, with an estimated 23.1% of Americans participating in heavy and/or binge drinking at least once a month. A safe and effective therapy for alcoholic liver disease (ALD) in humans is still elusive, despite significant advances in our understanding of ho...

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The toxic effects of amiodarone on the lung are well recognised, but the rapid onset of those effects, especially in the presence of high inspired oxygen concentrations, are perhaps not adequately appreciated. This may be a potential problem in the Intensive Care Unit (ICU) where amiodarone is frequently used in the treatment of tachydysrhythmias in patients with acute respiratory distress synd...

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ژورنال

عنوان ژورنال: American Journal of Gastroenterology

سال: 2019

ISSN: 0002-9270,1572-0241

DOI: 10.14309/01.ajg.0000599064.75682.73